NAT1、NAT2基因多态性与广东地区汉族人群喉癌遗传易感性研究

摘要

Objective:To analyze the association between genetic polymorphisms of NAT1,NAT2 and susceptibility to laryngeal squamous carcinoma (LSCC) in Han population in Guangdong China.Methods:A case-control study was conducted involving 233 LSCC patients and 102 healthy controls to investigate the association between polymorphisms of NAT1 (NAT1 * 4,NAT1 * 11,NAT1 * 10,NAT1 * 3)、NAT2 (WT,M1,M2 and M3) and LSCC in the Han population in Guangdong China.All blood samples were analyszed to explore the association between polymorphisms and the clinical pathologic characteristic of LSCC.Results:The frequency of high NAT2 genotype was lower in LSCC (18.88％) than that in healthy people (45.1％) (OR =2.53,P =0.00).There was cooperating effect between low NAT2 genotype and weightly smoking during carcinogenesis of LSCC(P =0.013,OR =3.42).There was no association between low NAT2 genotype and the clinical pathologic characteristic of LSCC.There was no difference of the frequency of NAT1 (NAT1 * 4,NAT1 * 11,NAT1 * 1 0,NAT1 * 3) genotype between LSCC and healthy people (P ＞0.05).Conclusion:There may be an association between the susceptibility to laryngeal carcinoma and the low NAT2 genotype.The genotype of low NAT2 cooperate with weightily smoking boost up the susceptibility of individual to laryngeal carcinoma.There may be no association between the susceptibility to laryngeal carcinoma and the NAT1 (NAT1 * 4,NAT1 * 11,NAT1 * 10,NAT1 * 3) genotype.%目的:探讨毒物代谢酶NAT1、NAT2基因多态性与广东地区汉族人群喉癌遗传易感性的关系.方法:采用病例-对照研究的方法,检测233例广东地区汉族喉癌和102例健康对照组外周血中NAT1(NAT1*4,NAT1* 11,NAT1*10,NAT1/3)、NAT2(WT、M1、M2和M3)基因多态性.结合病历资料分析NAT1、NAT2多态基因与喉癌临床病理特征之间的关系.结果:喉癌患者携带NAT2快基因表型(18.88％)频率小于正常对照组(45.1％)(OR =2.53,P=0.00).NAT2慢基因表型与重度吸烟在喉癌致病过程中有协同作用(P=0.013,OR =3.42).NAT2基因表型与喉癌的临床病理特征无关.喉癌与对照组中NAT1多态基因频率无显著性差别.结论:NAT2快基因表型与喉癌的易感性关联,易感性与吸烟发生协同作用.NAT2基因多态性不影响喉癌的发展过程及预后.NAT1基因多态性可能与喉癌的遗传易感性无关.