Stathmin在非小细胞肺癌中的表达及其临床意义

摘要

目的：检测stathmin在非小细胞肺癌（ non small cell lung cancer，NSCLC）组织中和正常肺组织中的表达，探讨其与NSCLC临床病理特征之间的关系。方法：免疫组化SP法，检测77例NSCLC组织及20例正常肺组织标本中stathmin蛋白的表达。结果：Stathmin蛋白在NSCLC组织中的阳性表达率为63.7%，显著高于正常肺组织的20.0%，差异具有统计学意义（ P<0.05）。Stathmin的表达与肿瘤的组织学分级、TNM分期、淋巴结转移正相关，差异具有统计学意义（ P<0.05）。结论：Stathmin在NSCLC的发生发展过程中起重要作用，可能成为预测NSCLC诊断及预后的新的生物学及个体化治疗的敏感指标。%Objective:To detect the expression of stathmin in non small cell lung cancer( NSCLC)and to explore its clinical significance. Methods:The expression of stathmin was detected in 77 cases of NSCLC and 20 cases of nor-mal tissue of lung by immunohistochemical method. Results:Significantly higher statnmin expression was found in the NSCLC(63. 7%)than in normal tissue of lung(20. 0%). There was a statistically significant difference(P<0. 05), and the expression of stathmin was correlated with histological grade,TNM stage( P<0. 05). There were statistically significan differences between the non small cell lung cancer with and without lymph node metastasis(P<0. 05). Conclusion:Stathmin play a key role on the development of NSCLC. Stathmin can be regarded as a marker for diagno-sis of NSCLC,and can be used for judging the prognosis. It could provide a new idea in the treatment.