Stathmin 基因在非小细胞肺癌中的表达

摘要

Objective:To detect the expression of Stathmin gene and its relationship with clinical features in non -small cell lung cancer(NSCLC).Methods:The expression of Stathmin gene was detected by immunohistochemistry in 135 patients with NSCLC and 20 lung specimens of paracarcinoma tissues as control.Results:The level of Stathmin gene expression in NSCLC was significant higher than that in the paracarcinoma tissues(P <0.05).Interestingly the Stathmin gene expression was remarkably related to the lymph node metastasis but not to tumor size,TNM staging, pathological type and patient's age,gender.Conclusion:Stathmin gene expression is up -regulated in NSCLC patients related to the lymph node metastasis.%目的：检测 Stathmin 基因在非小细胞肺癌组织中的表达，探讨其与临床病理因素的关系。方法：用免疫组织化学 SP 法检测135例非小细胞肺癌及20例癌旁肺组织中 Stathmin 蛋白的表达，分析其与患者年龄、性别、肿瘤分化程度等临床病理特征之间的相关性。结果：小细胞肺癌组织中 Stathmin 基因蛋白的表达水平明显高于癌旁肺组织（P ＜0．05），Stathmin 的表达与淋巴结转移有关（P ＜0．05）。结论：Stathmin 基因在非小细胞肺癌组织中的表达显著上调；Stathmin 基因的表达与淋巴结转移有关，而与年龄、性别、肿瘤大小、TNM分期、组织类型无关。