乳腺癌组织 VEGF - A、COX -2的表达与预后生存分析

摘要

To study the expression of postoperative tissue VEGF - A,COX - 2,and analyze the rela-tionship with the prognosis of breast cancer. Methods:Postoperative tissue VEGF - A,COX - 2 were detected by SP immunohistochemical technique. Relation of VEGF - A,COX - 2 with breast cancer's survival was analyzed by Cox proportional hazards model,Kaplan - meier and Log - rank methods. Results:The positive expression rate of VEGF -A was higher in breast cancer than benign disease(70. 00% ,44. 11% ),the positive expression rate of COX - 2 was higher in breast cancer than benign disease(66. 67% ,17. 65% ),and the positive expression rate of VEGF - A higher in the group of COX - 2 positive(80% ,50% ),all had the statistical significance(P ﹤ 0. 05). Patient's prognosis had the relationship wih clinical stage,lymph node status,C - erbB - 2,VEGF - A and COX - 2. Conclusion:Cox multi-variate regression analysis showed that the VEGE - A of breast cancer's postoperative tissue,clinical stage are the prognostic factors in breast cancer.%目的：检测乳腺癌术后组织中 VEGF - A、COX -2的表达，并进行随访，分析两者与乳腺癌患者预后的关系。方法：采用 SP 免疫组化法检测乳腺癌术后组织中 VEGF - A、COX -2的表达，并采用 Kaplan - meier法、Log - rank 法和 Cox 比例风险模型将两者的表达与乳腺癌患者生存期进行统计分析。结果：乳腺癌术后组织 VEGF - A 阳性表达率明显高于乳腺良性组织（70.00%、44.11%），COX -2阳性表达率亦高于乳腺良性组织（66.67%、17.65%），同时 COX -2阳性组患者的 VEGF - A 阳性率明显高于阴性组（80.00%、50.00%），且均有统计学意义（P ﹤0.05）；患者的临床分期、淋巴结转移状态、C - erbB -2、VEGF - A、COX -2与患者的预后有关。结论：多因素 Cox 回归分析显示乳腺癌组织 VEGF - A、临床分期是乳腺癌患者预后的影响因素。