康复新联合 rhG - CSF 防治放射性口腔炎的临床观察

摘要

To observe the prevention and cure effect of combine Kangfuxin with rhG - CSF(recombi-nant human granulocyte colony - stimulating factor)on radiation - induced oral mucositis. Methods:All 46 cases of head and neck malignant tumor patients who received radiotherapy were divided into two groups:The research group,23 cases,use the mouthwash contain Kangfuxin and rhG - CSF;the control group,23 cases,ues the mouthwash just contain rhG - CSF. Both the two groups were adopted conventional fractionated radiotherapy. The evaluation of radia-tion oral mucositis was done according to the systems proposed by RTOG. The occurrence time,incidence rate and the degree of injury were observed. Results:In research group and control group the occurrence time of radiation - in-duced oral mucositis were(28. 57 ± 1. 93)days and(19. 57 ± 1. 95)days respectively,the total incidences of radia-tion - induced oral mucositis was 65. 22% and 91. 30% respectively,the incidences of above grade 2 radiation - in-duced oral mucositis was 17. 39% and 47. 83% . All the differences were significant(P ﹤ 0. 05). Conclusion:Kang-fuxin combined with rhG - CSF could delay the occurrence time,reduce the incidence and degrade the degree of inju-ry on radiation - induced oral mucositis.%目的：观察康复新液联合 rhG - CSF（重组人粒细胞集落刺激因子）局部应用对放射性口腔炎的防治效果。方法：将46例经病理确诊的头颈部恶性肿瘤患者随机分为两组，实验组（23例）采用康复新液联合rhG - CSF 稀释后含漱，对照组（23例）采用 rhG - CSF 稀释后含漱，两组均采用常规分割方式放疗。采用全美放射肿瘤治疗协作组（RTOG）急性放射性黏膜炎的分级标准，观察放射性口腔炎的发生时间、发生率及严重程度。结果：实验组与对照组放射性口腔炎平均发生时间分别为（28.57±1.93）d 及（19.57±1.95）d，P﹤0.001。放射性口腔炎总发生率分别为65.22%及91.30%，P =0.032。2级以上放射性口腔黏膜损伤发生率分别为17.39%及47.83%，P =0.028。结论：康复新液联合 rhG - CSF 能够延迟放射性口腔炎出现时间，降低放射性口腔的发生率，并减轻其损伤程度。