EZH2在前列腺癌中的表达及临床意义

摘要

目的：研究EZH2在前列腺癌中的表达及临床意义。方法：利用免疫组化的方法研究EZH2在前列腺良性增生性病变组织与前列腺癌组织中的表达，分析EZH2的表达与肿瘤Gleason评分之间的关系。结果：EZH2在前列腺癌细胞中高表达，其高表达趋势与前列腺癌的Gleason评分水平成正相关。结论：EZH2蛋白的异常表达可能在前列腺癌的生长、浸润和转移过程中起促进作用，可能成为一种反映前列腺癌生物侵袭性的标志物。%Objective:To determine the expression of EZH2 in the prostate cancer tissues and to estimate its clini-cal significance. Methods:Immunohistochemistry was performed to detect EZH2 expression in malignant tumor of prostate and the tissue of benign neoplasia was used as the control. Results:EZH2 expressed with a much higher level in prostate cancer tissues with comparison to that in the benign neoplasia. And its expression trend was correlated with the malignant degree of the carcinoma. Conclusion:The abnormal expression of EZH2 could play a very important role in promoting the proliferation,invasion and metastasis of the prostate cancer,and the EZH2 could be a marker to re-flect the invasion ability of prostate cancer.