目的：探讨外周血中性粒细胞与淋巴细胞比值（NLR）对结肠癌肝转移射频消融术后肿瘤复发的影响。方法：回顾性分析98例行射频消融术的结肠癌肝转移患者临床资料。单因素分析术前最大肿瘤直径、肿瘤数目、结肠癌病理分期、CEA 水平、术前和术后 NLR 等对术后无瘤生存率的影响。有统计学意义的影响因素进入 Cox 回归模型行多因素分析。结果：1、3、5年的无瘤生存率分别为66.3%、28.6%和17.3%。单因素分析显示术前 NLR≥2.5和术后 NLR 升高影响术后无瘤生存率。NLR ﹤2.5和 NLR≥2.5的患者1、3、5年无瘤生存率分别为77.4%、35.8%、22.6%和53.3%、20.0%、11.1%（P ＝0.044）。术后 NLR 升高和不升高的患者1、3、5年无瘤生存率分别为52.3%、17.1%、8.6%和73.0%、34.9%、22.2%（P ＝0.022）。Cox 回归分析显示仅术后 NLR 升高为影响结肠癌肝转移射频消融术后复发的独立危险因素（P ＝0.029）。结论：术前NLR≥2.5及术后 NLR 升高的结肠癌肝转移患者射频消融术后肿瘤复发的风险增加。%Objective:To investigate the effect of PeriPheral blood neutroPhil - lymPhocyte ratio on the tumor re-currence of liver metastasis of colon cancer after radiofrequency ablation. Methods:To retrosPectively analyze 98 cases of radiofrequency ablation of liver metastasis of colon cancer. Univariate analysis was Performed on PreoPerative maxi-mal tumor diameter,tumor number,colon cancer staging,Pathological effects of CEA levels,PreoPerative and PostoPer-ative NLR with the PostoPerative disease - free survival rate,and then by multivariate analysis of Cox regression mod-el. Results:1,3,5 years disease - free survival rates were 66. 3% ,28. 6% and 17. 3% resPectively. Single factor a-nalysis showed PreoPerative NLR≥2. 5 and NLR after the oPeration affected increased PostoPerative disease - free survival rate. NLR ﹤ 2. 5 and NLR≥2. 5 were 1,3,5 years disease - free survival rates were 77. 4% ,35. 8% ,22. 6%and 53. 3% ,20. 0% ,11. 1% resPectively(P = 0. 044). Patients with elevated NLR after oPeration and no increased 1,3,5 years disease - free survival rate was 52. 3% ,17. 1% ,8. 6% and 73. 0% ,34. 9% ,22. 2% resPectively(P =0. 022). Cox regression analysis showed that only NLR elevation after oPeration was indePendent risk of recurrence of colon cancer liver metastasis after radiofrequency catheter ablation(P = 0. 029)factor. Conclusion:PreoPerative NLR≥2. 5 and NLR PostoPerative elevated liver metastasis of colon cancer after radiofrequency ablation in Patients were with an increased risk of tumor recurrence.
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