32P胶体介入治疗甲状腺囊腺瘤临床分析

摘要

目的：探讨32 P 胶体联合地塞米松治疗甲状腺囊腺瘤的疗效。方法：收集自2008年1月至2012年5月于本院确诊的甲状腺囊腺瘤患者112例，全部患者随机分为两组：32 P 胶体联合地塞米松治疗组56例，32 P胶体治疗组56例。患者治疗前后均查游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）、血清促甲状腺素（TSH）、甲状腺球蛋白（TG）、甲状腺微粒体（TM）及血常规。用超声及甲状腺显像测量囊腺瘤大小。用药1个疗程之后，经医学影像检测未发现瘤体，则判定治愈；经医学影像检测发现囊腺瘤直径缩小超过1／2，则判定有效；经医学影像检测发现囊腺瘤缩小不到治疗前1／2或无变化，则判定无效。结果：两组的治疗疗效比较有显著差异（P ＜0．05）。两组治疗前后甲状腺激素及血常规检查未发现异常变化，穿刺液未检出癌细胞。治愈病例随访2年未复发。结论：32 P 胶体联合地塞米松治疗甲状腺囊腺瘤安全且无创，疗效确切，治愈率高，可避免手术损伤，值得临床推广应用。%Objective:To evaluate the efficacy of 32 P combined with dexamethasone in treatment of cystic thyroid adenoma.Methods:All 112 patients that confirmed from 2008.1 -2012.5 were divided into treatment group(56 pa-tients)and control group(56 patients)randomly.Control group only used 32 P,while the treatment group adopted 32 P and dexamethasone.FT3,FT4,TSH,thyroglobulin(TG),thyroid microsomal(TM)and routine blood were measured and analyzed before and after treatment.Ultrasound and thyroid imaging were taken out to measure the size of cystic thyroid adenoma after 1 period of treatment.Curative:No tumor was found by imageological examination.Effective:The diameter of tumoer reduced more than 1 /2.Invalid:The diameter of tumoer reduced less than 1 /2 or unchanged.Re-sults:The efficacy showed significant change between 2 group(P <0.05).Yet the level of thyroid hormones and rou-tine blood showed no significantly change after treatment.No cancer cells were detected in puncture fluid.No recur-rence was found after 2 -year follow -up in curative patients.Conclusion:32 P combined with dexamethasone in treat-ment of cystic thyroid adenoma was a safe and recommendable method with creditable efficacy and higher curative rate.