乳腺癌患者血清中Six1的检测及临床意义

摘要

目的：检测乳腺癌患者及对照组患者血清中Six1的水平，分析临床意义。方法：收集乳腺癌75例、乳腺不典型增生35例、乳腺导管内乳头状瘤32例、乳腺纤维瘤28例及正常人30例，应用酶联免疫吸附试验（ ELISA法）检测Six1的水平。结果：乳腺癌患者血清中Six1水平明显高于乳腺不典型增生组、乳腺导管内乳头状瘤组、乳腺纤维瘤组及正常人群组（ F＝23.57，P<0.01）。乳腺癌患者中Six1的表达水平与年龄无关（ P>0.05），而与TNM分期、组织学分级、淋巴结状态及脉管浸润有关，差异具有统计学意义（ P<0.05）。结论：Six1与乳腺癌发生及侵袭转移相关，可为乳腺癌提供潜在的诊治靶点。%Objective:To detect the level of Six1 in breast cancer patients and control group patients,analyze its clinical significance. Methods:To collect 75 breast cancer serum,35 serum of atypical hyperplasia of the breast,32 intraductal papilloma serum,28 mammary gland fibroma serum and 30 normal serum. Use the ELISA method to detect the level of Six1,and evaluate the clinical significance of Six1. Results:The level of Six1 in breast cancer was higher than atypical hyperplasia of breast,intraductal papilloma,mammary gland fibroma and normal population(F=23. 57, P<0. 01). There was no relationship between age and the expression level of Six1 in breast cancer patients(P>0. 05),but between TNM staging,histological grade,node status and vascular lymphatic invasion,the difference was of significant(P<0. 05). Conclusion:Six1 is related to the genesis and development of breast cancer,it can provide potential target for breast cancer diagnosis and treatment.