高尔基蛋白73在原发性肝癌诊治中的意义

摘要

Objective:To evaluate the clinical value of serum Golgi protein 73( GP73 )as liver disease expecial the primary hepatic carcinoma( PHC ). Methods:Quantitative detection of serum GP73 and alpha - fetoprotein ( AFP)levels in patients with hepatic space-occupying lesions by using enzyme-linked immunosorbent assay andchemiluminescence method,furthermore,patients with PHC cirrhosis of liver as a control and healthy examination peo-ple as another terms. To patients with PHC,the relationship between serum GP73 levels and the clinical pathologic pa-rameters was analyzed. Results:The sensitivities,positive predictive values of GP73 lever in patients with hepatic space-occupying lesions were 77. 27% and 85. 71%,P<0. 05. Compared with patients with PHC cirrhosis of liver as a control and healthy examination people the lever of GP73. The serum level of GP73 in patients with PHC was sig-nificantly higher than that in patients with cirrhosis and healthy controls,P<0. 05. The serum level of GP73 in pa-tients with cirrhosis was higher than healthy controls,P<0. 05. There was no relationship between serum GP73 and age,gender and tumer amount in patients with PHC. There was some relationship between serum GP73 and tumer size tansfer Child stage and infection. Conclusion:As a new serum marker,GP73 can be used for diagnosis of PHC. More-over,it has important clinical value in analyzing pathogenetic condition,judging malignant degree and prognosis for PHC.%目的：评价高尔基蛋白73（Golgi protein 73，GP73）作为肝脏疾病尤其是原发性肝癌（primary hepatic carcinoma，PHC）血清学标志物的临床应用价值。方法：分别采用酶联免疫吸附试验和化学发光法定量检测肝占位患者的血清GP73及甲胎蛋白（ AFP）的水平以确定肝占位性质。同时选取PHC患者组、肝硬化患者组及健康体检组作为对照进行GP73水平测定。对PHC患者，进一步分析血清GP73水平与临床病理参数之间的关系。结果：肝占位组GP73的灵敏性及特异性分别为77.27％和85.71％，P<0.05。PHC组、肝硬化组及健康体检组GP73数据比较：PHC组患者GP73值明显高于其余两组，P<0.05。肝硬化组GP73血清含量高于健康体检组，P<0.05。PHC组各数据分组比较分析：GP73血清含量与性别、年龄、肿瘤数目无明显相关性，而与肿瘤直径、肿瘤转移情况、Child分级及肝炎感染情况具有相关性。结论：作为新型血清标志物，GP73与AFP一样，临床检测效果良好，与AFP临床诊断上具有互补性，可用于临床肝占位性质的判定、PHC的诊断，并且对于PHC病情分析、恶性程度判断乃至预后评估等均具有重要临床价值。