化疗对晚期非小细胞肺癌患者凝血四项的影响

摘要

Objective:To observe the clinical efficacy of chemotherapy for advanced non-small lung cancer cells as well as the impact on coagulation. Methods:All 67 cases of advanced non-small cell lung cancer patients were research subjects,healthy control group of 45 patients. Cancer patients were treated by chemotherapy. Results:The group of patients with advanced lung cancer before chemotherapy prothrombin time( PT),activated partial thrombo-plastin time( APTT),thrombin time( TT),fibrinogen( FIB),D-dimer were significantly higher than in healthy con-trols group,P<0. 05,the difference was statistically significant. Advanced lung cancer patients after chemotherapy significantly prolonged PT,APTT and TT was significantly shorter than that before treatment,FIB and D-dimer val-ues were significantly higher than before,P<0. 05,the difference was statistically significant. Conclusion:In patients with advanced non-small cell lung cancer treated by chemotherapy are with abnormal coagulation.%目的：观察晚期非小细胞肺癌化疗的临床疗效以及对凝血4项的影响。方法：选取67例晚期非小细胞肺癌患者作为研究对象，另设健康对照组45例。肺癌组患者采取化疗治疗，对比两组患者的凝血四项指标以及D-二聚体数值。结果：晚期肺癌组患者化疗前凝血酶原时间（ PT）、活化部分凝血活酶时间（ APTT）、凝血酶时间（ TT）、纤维蛋白原（ FIB）、D-二聚体均明显高于健康对照组，P值均<0.05，差异有统计学意义。晚期肺癌组患者化疗后PT显著延长，APTT和TT较治疗前明显缩短，FIB和D-二聚体值均较前明显升高，P值均<0.05，差异有统计学意义。结论：晚期非小细胞肺癌患者普遍存在凝血功能的异常，而化疗往往会加重血液的高凝状态。