化疗对晚期非小细胞肺癌患者凝血功能的影响

摘要

目的:探讨晚期非小细胞肺癌(NSCLC)患者化疗前后凝血指标的变化及临床意义.方法:对60例肺癌患者及20例健康人的血浆凝血酶原时间(PT)、纤维蛋白原(FIB)、部分活化凝血活酶时间(APTT)和 D-二聚体(D-D) )水平进行测定,同时计数血小板(PLT).结果:化疗前肺癌患者凝血指标凝血酶原时间、纤维蛋白原、部分活化凝血活酶时间、 D-二聚体、血小板与正常对照组比较有显著差异(P＜0.05);肺癌患者化疗后与化疗前各项指标相比有显著性差异(P＜0.05).结论:晚期NSCLC患者普遍存在凝血功能异常,化疗可改善患者的凝血功能.%Objective: To evaluate the variations of coagulation markers before and after chemotherapy in patients with advanced non - small ceU lung cancer.Methods :The plasma levels of coaSulation markers were detected in 60patients wich lung cancer and 20 nonnal controls.Results: Compared with the control group, the mean values of prothrombin time( PT) , fibrinogen( FIB) .activated partial thromboplastin time ( AP17) 、D - dimer( D - D) and platelet count ( PLT) were significantly increase ( P ＜ 0.05 ) in patients with NSCLC.The expressive rates of coagulation markers were lower in post - treatment patients than in pre - treatment samples ( P ＜ 0.05 ) .Conclusion; Coagulation disorder is common among advanced NSCLC patients.Chemotherapy may improve the coagulation function of patients with NSCLC.