目的：探讨根治切除术联合抗病毒治疗肝癌合并乙肝病毒（ HBV ）感染的临床效果。方法：选取2010年4月-2013年4月100例肝癌合并乙肝病毒感染患者为研究对象，按照HBV-DNA水平不同分成高病毒复制组和低病毒复制组（以HBV-DNA载量为105拷贝/ml为标准），比较四组在肝功能、HBV-DNA水平、生存时间、肿瘤复发率和住院时间、住院费用方面的差异性。结果：抗病毒治疗后无论在高病毒复制组和低病毒复制组中，肝功能明显好转，HBV-DNA水平明显低于未抗病毒治疗，且在住院时间、费用、生存时间和肿瘤复发率上抗病毒治疗均好于未抗病毒者，但低病毒复制者在住院时间、住院费用上优于高病毒复制者。在生存时间上高病毒复制者1~2年生存率更好，在肿瘤复发率上低病毒复制者更低。结论：抗病毒结合根治切除术能改善肝癌合并HBV感染者的肝功能和病毒指标，缩短住院时间，延长生存时间。%Objective:To investigate the effect of radical resection of hepatocellular carcinoma with combined anti-viral treatment of hepatitis B virus( HBV)infection. Methods:All 100 cases of hepatocellular carcinoma with hepati-tis B virus infection were selected and divided into groups of high and low viral replication of viral replication group ( in HBV-DNA load was 105 copies/ml as standard),again divided into groups with and without anti-virus treat-ment group. Results:The anti - viral therapy with high viral replication in both groups,and low viral replication group,significant improvement in liver function and HBV-DNA levels were significantly lower than those without an-tiretroviral therapy. In the length of hospital stay,cost expense and complications survival time antiviral treatment on tumor recurrence rate were better than those who were not anti-virus,but low viral replication were in complications and length of stay,hospital costs than those on high viral replication. Conclusion:The combination of antiviral radical resection can improve liver HBV infection in patients with liver function and viral indicators,shorter hospital stay.
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