CD147和Ki-67在甲状腺乳头状癌中的表达及意义

摘要

Objective:To investigate the mutation of CD147 and Ki-67 in PaPillary thyroid cancer and its clinical significances. Methods:Inmmunohistochemistry method was used to analyze the exPression of gene CD147 and Ki-67 in 50 cases PaPillary throid cancer,50 cases follicular adenoma and 50 cases of normal controls. Results:The ex-Pression of CD147 in PaPillary thyroid cancer was obviously higher than that in follicular adenoma and normal tissue (68% vs 20% vs 0). There was significant difference among PaPillary thyroid cancer,follicular adenoma and normal tissue(P<0. 001),and it was related to lymPh node metastasis and cancer and TNM stages(P<0. 05). No Ki-67 Protein exPression was observed in normal tissue. The rate of Ki-67 Positive exPression in PaPillary thyroid cancer, follicular adenoma were(36% vs 18%). There was significant difference between normal tissue,follicular adenoma and PaPillary thyroid cancer(P<0. 05). Conclusion:Positive exPression of CD147 and Ki-67 was mechanism of PaPillary thyroid cancer and they were involved in carcinogenesis. CD147 may be a novel Prognostic indicator of PaPil-lary thyroid cancer.%目的：探讨甲状腺乳头状癌组织中CD147和Ki-67表达情况及临床意义。方法：应用免疫组化法检测甲状腺乳头状癌、滤泡性腺瘤和正常甲状腺组织（各50例）中CD147和Ki-67的表达。结果：甲状腺乳头状癌组织中CD147阳性表达率明显高于滤泡性腺瘤和正常甲状腺组织（68% vs 20% vs 0），三者比较差异有统计学意义（P＜0.001）。CD147表达与淋巴结转移和TNM分期有关（P＜0.05）。正常甲状腺组织中Ki-67未见阳性表达，甲状腺乳头状癌、滤泡性腺瘤中阳性表达率为（36% vs 18%），三者比较差异有统计学意义（P＜0.05）。结论：CD147和Ki-67表达异常是甲状腺乳头状癌产生的机制之一，与甲状腺乳头状癌的发生及发展有关。CD147可能是甲状腺乳头状癌预后的一项重要预测指标。