胃癌组织中OPN表达及临床意义的Meta分析

摘要

目的：系统评价国内有关胃癌组织中OPN表达及临床意义的研究。方法：检索CBM、CNKI、VIP和万方数据库，并辅以文献追溯的方法，收集公开发表的所有关于胃癌组织中OPN表达及其与临床病理特征关系的病例对照研究。检索年限均为从建库至2014年8月20日。按纳入排除标准筛选文献并评价纳入研究质量后，应用RevMan 5.2软件进行Meta分析。结果：共纳入9个病例对照研究，其中胃癌组585例，对照组153例。Meta分析结果显示：OPN在胃癌组与对照组[ OR＝0.04，95%CI（0.02，0.07）]、高中分化组与低分化组[OR＝0.55，95%CI（0.34，0.89）]、临床Ⅰ-Ⅱ期组与临床Ⅲ-Ⅳ期组[OR＝0.20，95%CI（0.10，0.38）]、有淋巴结转移组与无淋巴结转移组[ OR＝3.24，95%CI（1.26，8.33）]的表达差异均有统计学意义。结论：目前国内证据证明，OPN可能参与了胃癌发生、发展的全过程，检测OPN表达有助于判断胃癌患者的预后。%Objective:To investigate the expression and clinical significance of osteopontin( OPN ) in gastric cancer with Meta-analyses. Methods:The published studies were searched in the CBM,CNKI,VIP and WanFang databases,and other relevant journals were also handsearched to identify all the relevant case -control trials. The quality of the included studies was assessed. The Cochrane Collaborationˊs software RevMan 5. 2 was used to test the heterogeneity,overall effect and publication bias of the combined studies. Results:A total of 9 studies were recruited. The positive of OPN in gastric cancer was significantly higher than this in control group tissues with OR(95%CI)at 0. 04(0. 02,0. 07). The level of OPN expression had a positive correlation with the histological grading,clinical stages with OR(95%CI),lymph node metastasis,at 0. 55(0. 34,0. 89),0. 20(0. 10,0. 38),3. 24(1. 26,8. 33),respective-ly. Conclusion:ccording to the domestic evidence,OPN may be participate the whole course of carcinogenesis of gas-tric cancer,and may be useful predicting the prognosis of gastric cancer.