康艾注射液对肝癌患者TACE术后生活质量的影响

摘要

目的：观察康艾注射液对中晚期肝癌患者TACE（肝动脉化疗栓塞术）治疗后生活质量的影响。方法：选择BCLC B期或C期的原发性肝癌患者67例，随机分为两组，观察组给予康艾注射液联合TACE治疗，对照组给予单纯的TACE治疗。术后第7天查血常规、肝肾功能评估毒副反应，于术前及术后第10天采用欧洲癌症研究及治疗组织生活质量核心量表（ EORTC QLQ-C30）评价患者生活质量的改变。结果：观察组白细胞减少、肝功能损害发生率小于对照组（ p<0.05）；观察组在降低症状领域评分，升高QLQ-30功能领域、总体健康状况领域评分方面显著优于对照组（ p<0.05）。结论：康艾注射液可以减轻中晚期肝癌患者TACE治疗后的毒副反应，改善肝癌患者的症状，提高生活质量。%Objective:To observe the efficacy of Kang′ai-injection on quality of life in patients with hepatocellu-lar carcinoma( HCC )after TACE( transarterial chemoembolization ). Methods:All 67 patients with HCC in BCLC stage B or C were randomly divided into the control group and the observation group. The observation group received Kang′ai-injection combined with TACE. The control group received only TACE. Blood routine,liver function and re-nal function were tested at the 7th day after TACE to evaluate adverse reactions. Patients completed the European Or-ganization for Research and Treatment of Cancer( EORTC)QLQ-C30 before TACE and at the 10th day after TACE to assess quality of life. Results:The occurrence rate of adverse reaction such as leucopenia and liver function damage were lower in the observation group than that in the control group(p<0. 05). The observation group were better than control group in reducing the scores of symptom domains and increasing the scores of functional domains and globe health domains(p<0. 05). Conclusion:Kang′ai-injection combined with TACE decrease adverse reactions and im-proves symptoms and quality of life of patients.