前列腺癌组织Clusterin与Survivin表达与PSA 的相关性分析

摘要

Objective:To study the correlation of PSA and expression of Clusterin and Survivin in prostate cancer tissue. Methods:Immunohistochemistry was employed to measure the expression of Clusterin and Survivin in 80 cases of prostatic cancer and 50 cases of benign prostatic hyperplasia( BPH)and PSA in plasma. Results:In prostatic canc-er tissue,the positive expression rates of Clusterin and Survivin were 57. 5%(46/80)and 48. 8%(39/80). In be-nign prostatic hyperplasia tissue ,the positive expression rates of Clusterin and Survivin were 0( 0/50 ),0( 0/50 ) ( p<0. 05). The positive expression of Clusterin and Survivin were related with the histologic grade,clinical stage and metastasis of prostatic cancer and PSA(p<0. 05). The expression of Survivin was not correlated with Clusterin ex-pression in prostatic cancer(p>0. 001). Conclusion:The expression of Clusterin and Survivin and PSA in PCa may offer a new mode for the prevention and treatment of prostatic cancer.%目的：分析蛋白Clusterin和Survivin在前列腺癌（ PCa）组织中的表达与前列腺特异性抗原（ PSA）的相关性及在前列腺癌诊断中的应用价值。方法：应用免疫组织化学方法检测80例前列腺癌和50例前列腺增生组织凋亡蛋白 Clusterin、Survivin的表达和相应患者血浆中PSA值。结果：前列腺癌组织中Clusterin、Sur-vivin蛋白的阳性表达率分别为57.5%（46/80）、48.8%（39/80），Clusterin和Survivin蛋白在前列腺增生组织中的阳性表达率分别为0（0/50）、0（0/50），差异具有统计学意义（ p<0.05）。Clusterin和Survivin蛋白表达与前列腺癌病理分级、临床分期、转移情况和PSA具有相关性（p<0.05），前列腺癌组织中Survivin与Clus-terin 的表达无相关性（ p>0.001）。结论：联合检测Clusterin及Survivin表达与前列腺特异抗原（ PSA）可为前列腺癌的防治和治疗提供新的思路。