LncRNA 在胶质瘤中的研究进展

摘要

长链非编码 RNA（long non －coding RNA，LncRNA）是一类长度大于200个核苷酸的非编码RNA（non －coding RNA，ncRNA），虽然不编码蛋白质，但作为非编码 RNA 与肿瘤的发生发展有着密切关系。LncRNA 可在转录水平、转录后水平调控及表观遗传学三个层面影响肿瘤的增殖、凋亡、侵袭转移等生物学特性。本文介绍与胶质瘤发生发展关系密切的长链非编码 RNA，阐述其调节胶质瘤增殖、凋亡、血管生成及侵袭转移的机制。%Long non -coding RNA is a kind of non -coding RNA molecule which is longer than 200 nucleotides. Although it does not have the capacity of protein coding but it relates closely to tumorigenesis.LncRNA affects the oc-currence and development of glioma through transcriptional regulation post -transcriptional regulation and epigenetic effects.This paper introduces long noncoding RNAs that closely related to the occurrence and development of glioma, explains the effects of glioma cell proliferation,apoptosis,invasion and angiogenesis mechanisms.