Objective:To investigate the expression and clinical significance of DOG1 in gastrointestinal stromal tumors (GIST).Methods:Using immunohistochemistry Envision method,we tested DOG1 expression among 73 cases of GIST and 26 cases of non -GIST mesenchymal tumors,and analyzed the relationship between various clinicopatho-logical parameters of GIST and DOG1.Results:Among 73 GIST cases,positivity rates of DOG1,CD117 and CD34 were 91.78%,94.52% and 91.78% respectively,while in 26 cases of non -GIST positive rates were 11.54%, 3.85% and 23.08%(P =0.000).The detection sensitivity and specificity of DOG1 in GIST were 91.80%,88.50%. It was the highest of sensitivity while DOG1 joint CD117 detected and the sensitivity and specificity were 98.60% and 84.60% respectively.The expression of DOG1 in GIST was not associated with gender,age,tumor location,tumor size,mitosis,and malignancy potential grading (P >0.05),and also not related to prognosis (P >0.05).Conclu-sion:For diagnosing GIST,DOG1 has high sensitivity and high specificity as CD117.Especially for CD117 negative cases,DOG1 can be a complementary marker but cannot be used as prognostic indicator of GIST.%目的：探讨 DOG1在胃肠道间质瘤（GIST）中的表达及其临床意义。方法：免疫组化 Envision 法对73例 GIST 和26例非 GIST 间叶源性肿瘤检测 DOG1的表达，分析 DOG1与 GIST 的各项临床病理参数之间的关系。结果：在73例 GIST 中 DOG1、CD117和 CD34的阳性率分别为91．78％、94．52％和91．78％，而在26例非GIST 中阳性率为11．54％、3．85％ 和23．08％，以上指标在两组间的表达有统计学差异（P ＝0．000）；DOG1检测 GIST 灵敏度和特异度分别为91．80％、88．50％，而 DOG1联合 CD117检测 GIST 灵敏度和特异度分别为98．60％和84．60％，灵敏度最高；DOG1的表达与 GIST 的性别、年龄、肿瘤的位置、肿瘤的大小、核分裂象和恶性潜能分级等临床病理因素无相关性（P ＞0．05），同时 DOG1的表达与 GIST 的预后也无相关性（P ＞0．05）。结论：在 GIST 的诊断中 DOG1与 CD117一样是敏感而特异的指标，尤其是对 CD117阴性的 GIST 的诊断中，能够起很好的补充作用，但不能作为评价 GIST 预后的指标。
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