18F－FDGPET／CT最大标准摄取值与肺癌临床病理特点的关系

摘要

Objective:To investigate the relationship between the maximum standardized uptake value (SUVmax ) detected by 2 -(18 F)-fluoro -2 -deoxy -D -glucose -positron emission tomography (18 F -FDG -PET)/com-puted tomography (CT)and clinicopathological characteristics in patients with lung cancer.Methods:18 F -FDG PET/CT scanners was performed in 116 pathologically proven lung cancer patients before the treatment.Clinicopatho-logical factors which might affect SUVmax were evaluted,including gender,age,smoking history,WHO performance sta-tus,primary gross tumor volume (GTV),histological type,hemoglobin level,tumor locations,TNM stage,T factor,N factor.Results:The SUVmax in squamous carcinoma,adenocarcinoma,small -cell lung cancer were 19.37 ±7.88, 16.75 ±9.29,13.71 ±7.14,respectively.The SUVmax in small -cell lung cancer was smaller than that of squamous carcinoma groups (P =0.008)and there were no significant differences between other groups(P >0.05).The SUVmax was positively correlated with TNMstage(r =0.186,P =0.046).Generally there was no correlation between the GTV and the SUVmax in the 1 1 6 patients (r =0.015,P =0.873),excepted the group with GTV <45.3cm3 (r =0.456,P=0.013).Conclusion:The SUVmax of the primary tumor differed significantly between squamous carcinoma and small -cell lung cancer in patients.The SUVmax was positively correlated with TNMstage.When the volume of GTV is<45.3cm3 ,there is correlation between SUVmax and GTV,and small lesion often has lower SUVmax .%目的：探讨18 F －脱氧葡萄糖（18 F －FDG）正电子发射计算机断层扫描（PET／CT）最大标准值（SUVmax ）与肺癌 TNM分期、病理类型、原发肿瘤体积（primary gross tumor volume，GTV）等临床特征的关系。方法：对116例肺癌患者治疗前行 PET／CT 检查获得 SUVmax ，根据患者不同的临床及病理参数进行分组，采用单因素方差分析（ANOVA）比较不同组间 SUVmax的差异，SUVmax与 GTV 大小、血红蛋白水平及年龄计量资料的相关性采用 Pearson 相关分析，与 T 分期、N 分期、TNM分期等级资料的关系采用 Spearman 秩相关分析。结果：肺鳞癌组、腺癌组、小细胞癌组 SUVmax 分别为19．37±7．88、16．75±9．29和13．71±7．14，小细胞癌组SUVmax较鳞癌组低（P ＝0．008），两者 SUVmax差异显著，而在其他各组间差异无统计学意义（P ＞0．05）。肿瘤大小、TNM分期与 SUVmax之间的单因素相关分析 P 值分别为0．873、0．046，r 分别为0．015、0．186，总体上，肿瘤 SUVmax与病灶大小无关，但当病灶＜45．3cm3时，肿瘤 SUVmax与病灶大小中度相关（r ＝0．456，P ＝0．013）， SUVmax与 TNM分期之间呈正相关关系。结论：18 F －FDG PET／CT SUVmax在提示肺癌病理学类型方面有一定帮助，SUVmax随肿瘤大小和病期的增加呈升高趋势，可以作为预测肺癌 TNM分期的参考指标。