砷剂联合全反式维甲酸治疗 M3型小儿急性早幼粒细胞白血病

摘要

目的：探讨全反式维甲酸联合使用亚砷酸治疗 M3型小儿急性早幼粒细胞白血病的临床疗效。方法：选取我院2010年1月至2013年7月收治的80例急性早幼粒细胞白血病患儿，随机分为观察组和对照组，每组40例。观察组给予全反式维甲酸（ATAR）联合亚砷酸治疗，对照组给予 ATAR 进行治疗。两组患者均接受2个疗程的治疗，治疗过程中达到完全缓解（CR）的患者改用维持治疗。测定患者经过2个疗程治疗后的血象和骨髓象，并评价两组患者的治疗效果。结果：与单纯使用 ATAR 治疗相比，采用 ATAR 联合亚砷酸治疗，可以使患者更快的恢复血红蛋白水平和血小板数量；同时可以显著抑制患儿骨髓内的细胞异常增生和分化。疗效结果也表明，联合治疗 APL 可以显著的增加疗效，且能显著降低复发人数和复发率。结论：ATAR联合亚砷酸治疗 APL 效果可靠，起效迅速，值得临床推广使用。%Objective:To investigate the effect of all - trans retinoic acid and arsenic trioxide in acute promyelo-cytic leukemia. Methods:All 80 cases of pediatric leukemia patients with acute promyelocytic cells were randomly di-vided into observation group and control group. Observation group received all - trans - retinoic acid(ATAR)com-bined with arsenic trioxide treatment,patients in the control group given ATAR treatment. All patients received two courses of treatment. Results:Compared with the simple ATAR treatment,combined with the arsenic trioxide ATAR treatment,patients can recover faster in hemoglobin level and platelet count,at the same time can significantly inhibit the bone marrow dysplasia. The results also showed that the efficacy of the combination therapy of APL can significant-ly increase the efficacy of APL,and significantly reduce the number of relapse and recurrence rate. Conclusion:ATAR effect combined with arsenic trioxide therapy APL is reliable,rapid onset.