JAK2信号通路与肿瘤血管新生

摘要

JAK2是 JAK 家族的成员之一，JAK2与 STAT 家族的多个成员共同构成多条信号转导通路，如JAK2／STAT3、JAK2／STAT5等。JAK2／STATs 信号通路通过配体和细胞表面的受体结合而诱导受体二聚化，并相互磷酸化，从而激活 JAK。激活了的 JAK2／STAT 信号通路参与了肿瘤的发生、发展、血管新生、侵袭和转移等多个环节。研究表明肿瘤细胞中活化的 JAK2／STATs 信号通路主要是通过上调多种血管生成相关因子如血管内皮生长因子（VEGF）、环氧化酶－2（COX －2）等表达来促进肿瘤血管生成，IFN －α、SHP －1、SOCS通过 JAK2／STATs 通路下调肿瘤细胞促血管生成因子表达，抑制肿瘤血管生成。本文就 JAK2信号通路与肿瘤血管新生作一综述。%JAK2 is a member of the JAK family,and constitutes multiple signal transduction pathways with multiple members of the family of the STAT,such as JAK2 /STAT3,JAK2 /STAT5.JAK is activated by JAK2 /STATs signaling pathways through the ligands and receptors on the surface of cells and inducing receptors dimerization and phosphoryl-ation each other.The generation,development angiogenesis,invasion and metastasis of the tumor,and other links are taken part in by activation of JAK2 /STAT signaling pathways.Activation of JAK2 /STATs of tumor cells induces the tumor angiongenesis by activating the transcription of various associated factor of angiongenesis such as vascular endo-thelial growth factor(VEGF),cyclooxygenase -2(COX -2).Interferons alpha,SHP -1,SOCS reduce proangiogenic factors expression through JAK2 /STATs pathways to inhibit angiogenesis.The JAK2 signaling pathway and angiogene-sis is reviewed in this article.