H19多态性和肿瘤易感性关联的Meta分析

摘要

目的:探讨H19多态性与肿瘤易感性之间的关系.方法:检索PubMed,Embase与Web of Science数据库得到H19基因多态性与肿瘤易感性的病例对照研究,采用比值比(OR)和95％可信区间(95％Cl)评价关联强度.然后进行亚组分析、敏感性分析和文献发表偏倚检验.结果:最终纳入5篇病例对照研究,包括6 207例肿瘤患者和7 072例健康对照.分析后发现H19 rs217727多态性与肿瘤易感性无关(AA vs GG:OR=1.11,95％ CI 0.83 ～ 1.48, Ph=0.01,I2=69.5％;GA vs GG:OR=0.88,95％ CI 0.73 ～ 1.06,Ph=0.02,I2=65.0％;GA/AA vs GG:OR =0.94,95％ CI 0.78～ 1.12,Ph =0.02,I2=66.3％;AA vs GG/GA:OR=1.19,95％CI 0.93 ～ 1.53,Ph =0.02,I2 =64.9％).同样地,按照亚组分析提示在亚洲人中存在相同结果.然而,H19rs2839698多态性与肿瘤易感性相关(TT vs CC:OR=1.30,95％ CI 1.01 ～ 1.68, Ph=0.17,I2=40.6％;TT vsCC/CT:OR=1.30,95％ CI 1.07 ～ 1.59, Ph=0.31,I2=15.7％).结论:H19 rs217727多态性与肿瘤易感性无关,H19 rs2839698多态性与肿瘤易感性相关.%Objective:To evaluate the association between the H19 polymorphisms and the risk of cancer.Methods:PubMed,Embase and Web of Science was searched to get the case-control study on the association between H19 polymorphisms and cancer susceptibility.Odds ratio (OR) and 95％ confidence interval (CI) were calculated to evaluate the strength of the associations.Then subgroup analysis, sensitivity analysis, and publication bias were performed.Results:Five studies were included, involving a total of 6 207 cancer cases and 7 072 healthy controls.No statistical relationship was observed between H19 rs217727 polymorphism and cancer risk (AA vs GG:OR =1.11,95％ CI 0.83 ～ 1.48, Ph =0.01,I2 =69.5 ％, GAvs GG:OR =0.88,95 ％ CI 0.73 ～ 1.06, Ph =0.02,I2 =65.0％, GA/AA vs GG:OR =0.94,95％ CI 0.78 ～ 1.12, Ph =0.02,I2 =66.3 ％, AA vs GG/ GA:OR =1.19,95％ CI 0.93 ～1.53,Ph =0.02,I2 =64.9％).Similarly, subgroup analysis in Asian showed no significant association between rs217727 and cancer susceptibility.However, the H19 rs2839698 polymorphism was associated with risk of cancer (TT vs CC:OR =1.30,95％ CI 1.01 ～ 1.68,Ph =0.17,I2 =40.6％, TT vs CC/CT:OR =1.30,95％ CI 1.07 ～1.59,Ph =0.31,I2 =15.7％).Conclusion:The H19 rs217727 polymorphism might not be associated with overall cancer risk.However,The H19 rs2839698 polymorphism is associated with risk of cancer.