Objective To evaluate the effects of raw atractylodes on the small intestine propulsion rate, the expressions of tyrosine kinase receptor and stem cell factor mRNA in the rats rushing into the plateau, ex-plore the mechanism of the gastrointestinal motility dysfunction when suddenly exposed to the high altitude. Methods Hypobaric oxygen chamber was used to establish model of rushing into the high altitude at differ-ent altitude levels. 70 Wistar rats were randomly divided into 7 groups: control group (Lanzhou elevation, 1 430 m), at a altitude of 3 500 m model group with and without trimebutine maleat treatment and 5 000 m model group with and without raw atractylodes treatment. 72 h afte lavaged with 2 mL ink, the rats were sac-rificed and, the small intestinal propulsion rates of rats were measured after 30 min, and the expressions of C-kit and SCF mRNA in gastric antrum tissue were detected by reverse transcriptase polymerase chain reaction. Results Compared with control group, in 3 500 m model group the expressions of C-kit mRNA and SCF mRNA were reduced, small intestinal propulsion rates were lower (P<0.05);5 000 m model group showed in-creased C-kit mRNA expression and small intestinal propulsion rates (P<0.05) and reduced SCF mRNA ex-pression (P<0.05), the C-kit mRNA expression in trimebutine maleate group at 3 500 m altitude was higher (P<0.05), in at 5 000 m altitude group with trimebutine maleate treatment the espressions of C-kit mRNA and SCF mRNA and small intestine propulsion rate were reduced (P<0.05). The C-kit mRNA expression and small intestinal propulsion rates were enhanced in 3 500 m group with raw atractylodes treatment (P<0.05), were declined at 5 000 m group with raw atractylodes treatment (P<0.05), SCF mRNA expression was elevat-ed at 5 000 m group with raw atractylodes treatment (P<0.05). Conclusion Rushing into plateau can induce gastrointestinal motility disorder, which potentially related to C-kit and SCF mRNA expression level, and raw atractylodes can effectively treat the disease.%目的：研究生白术对急进高原大鼠小肠推进率及酪氨酸激酶受体C-kit和干细胞因子（SCF） mRNA的影响，探讨急进高原引起胃肠道运动功能障碍的发生机制和生白术防治的有效性。方法利用低压氧舱建立不同海拔高度的急进高原模型。70只Wistar大鼠随机分为7组：对照组（兰州海拔，1430 m）、海拔3500 m及海拔5000 m模型组、马来酸曲美布丁组、生白术组。造模72 h后各组大鼠给予2 mL墨汁灌胃，30 min后处死，测量每只大鼠小肠推进率，反转录聚合酶链反应检测胃窦组织C-kit mRNA和SCF mRNA的表达。结果与对照组相比，3500 m模型组C-kit mRNA、SCF mRNA的表达和小肠推进率降低（P<0.05）；5000 m模型组C-kit mRNA的表达和小肠推进率升高（P<0.05），SCF mRNA表达下降（P<0.05）；3500 m马来酸曲美布汀组大鼠C-kit mRNA表达升高（P<0.05）；5000 m马来酸曲美布汀组大鼠C-kit mRNA、SCF mRNA的表达和小肠推进率下降（P<0.05）；3500 m生白术组C-kit mRNA的表达和小肠推进率升高（P<0.05）；5000 m生白术组C-kit mRNA的表达和小肠推进率下降（P<0.05），SCF mRNA表达上升（P<0.05）。结论急进高原导致胃肠道运动功能紊乱，与C-kit及SCF mRNA表达变化有关，生白术可纠正急进高原胃肠道运动功能紊乱。
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