TPF方案对比PF方案诱导化疗后联合同期放化疗治疗局部晚期鼻咽癌的Meta分析

摘要

目的 系统评价紫杉醇/多西他赛+顺铂+氟尿嘧啶(TPF)方案和顺铂+氟尿嘧啶(PF)方案诱导化疗后联合同期放化疗治疗局部晚期鼻咽癌的疗效.方法 检索数据库PubMed(1950-2016年10月)、EMbase(1978-2016年10月)、The Cochrane Library (2016)、中国生物医学文献数据库(1978-2016年10月)、维普中文科技期刊数据库(2010---2016年10月)、中国CNKI学术总库(2010-2016年10月),中国重要会议论文全文数据库(2010-2016年10月)、中国学术会议论文全文数据库(2010-2016年10月),并辅以手工检索.采用RevMan 5.0软件进行Meta分析.结果 共9个随机对照试验551例患者纳入研究,提示TPF组较PF组在总有效率、完全缓解率方面具有优势,不良反应方面TPF组均高于PF组.结论 TPF组对比PF方案诱导化疗后联合同期放化疗治疗局部晚期鼻咽癌的总有效率优于PF组,不良反应高于PF组,但无明显的Ⅳ度不良反应,不良反应尚可耐受.%Object To evaluate the efficacy of taxol+ cisplatin+5-fluorouracil (TPF) versus cisplatin+5-fluorouracil (PF) induction chemotherapy followed by chemoradiotherapy for local advanced nasopharyngeal carcinoma.Methods PubMed (1950-2016-10),EMbase(1978-2016-10),the Cochrane Library (2016),Chinese Biomedical Literature Database (1978-2016-10),China Journal Full-text Database (2010-2016-10),CNKI (2010-2016-10) and Chinese Scientific Journal Full-text Database (2010-2016-10) were searched.And Meta-analysis was peformed using RevMan 5.0 software.Results A total of 9 randomized controlled trials involving 551 patients were studied.The result of Meta-analysis showed that there was significant difference in remission rate and complete total effective rate and such a difference was also noted in the side effects.Conclusion TPF group in the response rate was better than that of PF and the adverse reactions was higher than the PF group,but no obvious Ⅳ degree of adverse reactions were produced and,in general,the adverse reactions could be tolerated.