乳腺癌组织 CCR7的表达及其与上皮间质转化的关系

摘要

Objective To investigate the association between the expression of CCR7 and clinical parameters in human breast carcinoma and analyze the relationship between CCR 7 and the epithelial‐mesenchymal transition (EMT) .Methods CCR7 ,Slug and N‐cadherin were examined by immunohistochemistry in 56 cases of breast car‐cinoma tissues .The correlation between clinical parameters and CCR7 expression were retrospectively analyzed . Results 1)The expressions of CCR7 in lymph node metastasis group were significantly higher than those in the group that without lymph node metastasis (χ2 = 5 .061 ,P < 0 .05) .2)The expression of CCR7 in human breast cancer increased with the increase of the pathological stage of the patients .3)High expressions of CCR7 ,Slug and N‐cadherin were found in human breast carcinoma and the positive rate was 60 .71% ,66 .07% and 76 .78 % re‐spectively .4)The CCR7 expression was significantly associated to Slug and N‐cadherin( P < 0 .001) .Conclusion CCR7 was closely related to EMT indicators (Slug and N‐cadherin) in human breast carcinoma .CCR7 may play a role in the genesis of EMT in human breast carcinoma and be expected to become the biomarker of cancer metasta ‐sis .%目的：研究趋化因子受体‐7（chemokine receptor 7，CCR7）在乳腺癌组织中的表达及临床意义，并探讨 CCR7与上皮间质转化（epithelial mesenchymal transformation ，EM T ）的关系。方法采用免疫组织化学检测 CCR7、EM T 相关标志物转录因子 Slug 和 N‐cadherin 的表达，分析 CCR7与患者病理特征的关系。结果1） CCR7在淋巴结转移组的表达明显高于无淋巴结转移组（χ2＝5.061，P＜0．05）；2）CCR7在人乳腺癌组织的表达随患者病理分期的增加（Ⅰ→Ⅳ）而增加；3）CCR7、Slug 和 N‐cadherin 在人乳腺癌组织中均呈高表达，阳性率分别为60．71％（34／56）、66．07％（37／56）、76．78％（43／56）；4）CCR7与 Slug 、N‐cadherin 在乳腺癌组织的表达均呈正相关（P＜0．05）。结论 CCR7在人乳腺癌组织中的表达与 EM T 的指标密切相关，可能是判断癌转移的特异性指标。