目的 探讨正规抗结核治疗对初治肺结核患者血清中血管活性肠肽水平的影响及其与Th1型细胞因子γ-干扰素和Th2型细胞因子白细胞介素(IL)-4的相关性.方法 选择45例初治肺结核患者,其中30例Ⅲ型肺结核患者进行正规治疗2个月,观察血管活性肠肽、白细胞介素-4、γ-干扰素的变化情况,并与15例Ⅱ型肺结核患者及健康对照组相比较.结果 肺结核组血清VIP和IL-4水平均高于对照组,γ-干扰素水平低于对照组,Ⅲ型肺结核患者抗结核治疗2个月后,血清VIP和IL-4均明显低于治疗前,γ-干扰素水平明显低于对照组.结论 正规抗结核治疗2个月后,肺结核患者血清VIP水平明显下降,提示VIP对评价抗结核疗效具有一定的参考意义.%Objective To investigate the influence of regular anti-TB treatment on serum levels of vasoactive intestinal peptide in patients with pulmonary tuberculosis under initial treatment and the relationships between it and Thl type cytokine ?y-interferon or Th2 type cytokine interleukin (IL) -4. Methods 45 patients with newly diagnosed tuberculosis patients were selected, in which 30 cases of type III tuberculosis underwent regular treatment of anti-tuberculosis for 2 months. And the data of the changes of the vasoactive intestinal peptide , IL -4, and γ-interferon were observed. Meanwhile the data of the 15 cases of type II tuberculosis and healthy controls as compared. Results The serum VIP and IL-4 levels in the tuberculosis group were higher than those in the control group, while the serum-y-interferon levels lower. The serum VIP and IL-4 in HI pulmonary tuberculosis patients after 2 monthsanti-TB treatment were significantly lower than those before treatment, and Γ-interferon levels were significantly lower than those in the control group. Conclusions The serum VIP levels in the pulmonary tuberculosis patients significantly decreased after 2-month regular anti-TB treatment, suggesting that VIP had some reference significance on the evaluation of anti-TB.
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