Objective To investigate the clinical features of pediatric patients with systemic lupus erythematosus (SLE ). Methods The medical record of the first time hospitalization were retrospectively reviewed in pediatric patients with SLE. Results There were 104 patients with 17 boys and 87 girls. The first common symptom was facial rash (71.2%), fever (62.5%), joint pain (60.5%), acral erythema (49.0%). Among them, 38 patients had renal involvement. The pathological types were focal proliferative ( III , 26.3% ), diffuse proliferative ( IV , 57.1% ), and membrane type ( V , 18.4% ). In the early stage, the rash, hematuria, proteinuria, serous effusion, interstitial lung changes, the number of organs involved, the number of critical cases, disease activity index ( SLEDAI points ) were significantly different between girls and boys ( all P < 0.05 ). Conclusions The onset of most pediatric SLE occurs in early adolescence, and it is more common in girls. Boys had an earlier onset than girls, with more serious clinical symptoms, multiple organ involved, prominent renal involvement and a more rapid progression.%目的 探讨系统性红斑狼疮(SLE)患儿的临床特点.方法 对2003年3月 - 2010年10月确诊的104例SLE患儿首次住院病史进行回顾性分析.结果 104例患儿中男17例、女87例.首发症状以面部皮疹(71.2%)、发热(62.5%)、关节肿痛(60.5%)、肢端红斑(49.0%)多见;其中38例累及肾脏的病理分型为局灶增生型(Ⅲ,26.3%)、弥漫增生型(Ⅳ,57.1%)、膜型(Ⅴ,18.4%).男性患儿发病初期,皮疹、血尿、蛋白尿、浆膜腔积液、肺间质改变、受累器官数、危重症病例数、疾病活动性指数(SLEDAI积分)等与女性患儿的差异有统计学意义(P均＜ 0.05).结论 儿童SLE多发于青春期,女性多见.男性患儿发病年龄较女性早,临床症状重,器官受累多,肾脏受累突出,病情进展快.
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