目的 检测武汉地区住院呼吸道感染患儿非细菌病原体IgM抗体,为临床诊疗提供依据.方法 取诊断为呼吸道感染的12 125例住院患儿的血清,采用间接免疫荧光法检测9种呼吸道感染非细菌病原体的IgM抗体.结果 3 597份标本(29.7％)非细菌病原体IgM抗体检测阳性,其中肺炎支原体(MP)的阳性率最高为21.6％,其次为腺病毒(ADV)和乙型流感病毒(Flu B),阳性率最低为肺炎衣原体(CP)和Q热立克次体(COX)；混合感染563例,其中主要是2种病原体的混合感染.各年龄组(0～ 30d、～6个月、～1岁、～3岁、～9岁)的总检出率分别为30.4％、18.7％、35.4％、68.4％、55.2％,各组间差异有统计学意义(x2=89.5,P＜0.05).冬季非细菌病原体检出率最高(53.4％),秋季最低(24.9％),差异有统计学意义(x2=760.3,P＜0.05).结论 武汉地区呼吸道感染患儿的非细菌病原体主要是MP、ADV和Flu B; MP和其他非细菌病原体的混合感染比较普遍；1～3岁幼儿感染率较高；冬季更易感.%Objective To detect non-bacterial pathogen IgM antibody in hospitalized children with respiratory tract infection in Wuhan area; provide evidence for clinical diagnosis and treatment. Methods Nine of non-bacterial pathogen IgM antibodies in serum of 12 125 hospitalized children diagnosed as respiratory tract infections were tested by indirect immunofluorescence assay. Results Non-bacterial pathogen IgM antibodies positive were found in 3 597 specimens (29.7%) , among these results the MP-positive rate is highest (21.6%) , followed by adenovirus (ADV) and influenza B virus (FluB) , the lowest positive rate was Chlamydia pneumoniae (CP) and Q fever Coxiella's body (COX). Mixed infections were found in 563 children with mainly two kinds of mixed infection. The total detection rate were 30.4%, 18.7%, 35.4%, 68.4% and 55.2% respectively in age groups (0 - 30 d, - 6 months, - 1 y, - 3 ys, - 9 ys) and the differences among groups were statistically significant (x2 = 89.5, P < 0.05). The highest detection rate of pathogens was found in winter (53.4%) and the lowest was in autumn (24.9%) with significant difference between (X2 = 760.3, P < 0.05). Conclusions The main non-bacteria pathogens in children with respiratory tract infection in Wuhan are Mycoplasma pneumoniae, adenovirus and influenza B virus. Mixed infections of MP and other pathogens are common, the infection rate in children aged 1 to 3 is high and winter is susceptible season.
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