目的：探讨血清上皮型脂肪酸结合蛋白（E-FABP）与肥胖儿童心血管疾病危险因素的相关性。方法入选30例代谢综合征（MS）儿童，32例非MS肥胖儿童以及50例正常对照儿童，检测并比较其E-FABP水平、糖脂代谢指标等的差异。结果与对照组相比较，MS组血清E-FABP水平升高，差异具有统计学意义（P=0.001）；与非MS肥胖组相比，MS组血清E-FABP水平有升高趋势，但差异无统计学意义（P>0.05）。血清E-FABP水平与腰臀比、腰高比、动脉粥样硬化指数、空腹胰岛素、胰岛素抵抗指数呈正相关（P<0.05）。以E-FABP为自变量其余各指标为因变量，经多元逐步回归分析，影响儿童E-FABP水平的独立危险因素是动脉粥样硬化指数（P=0.018）。结论 E-FABP在肥胖和MS动脉粥样硬化的发生和发展过程中有一定的作用。%Objective To study the relationship between the level of serum epithelial fatty acid binding protein (E-FABP) and cardiovascular disease in obese children. Methods Thirty children with metabolic syndrome (MS), 32 obesity children with no MS and 50 healthy children were recruited. Serum E-FABP and glucose/lipid metabolic indices were measured. Results Com-pared with the healthy children, levels of serum E-FABP in MS children were signiifcantly elevated (P=0.001). Compared with obesity children, levels of serum E-FABP of MS children were elevated, but the difference was not signiifcant (P>0.05). The cor-relations of E-FABP with waist to hip ratio, waist-to-height ratio, atherogenic index, fasting insulin, insulin resistance index were positive (P<0.05). According to the multivariate stepwise regression analysis, E-FABP was the independent risk of atherogenic index (P=0.018). Conclusions E-FABP plays a role in the development of atherosclerosis in obesity and MS.
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