社区获得性肺炎患儿血清维生素A水平变化及意义

摘要

Objective To explore the changes and significance of serum vitamin A levels in children with community acquired pneumonia. Methods A total of 80 children with community-acquired pneumonia (pneumonia group) were selected from October 2015 to March 2016 and were divided into Mycoplasma pneumoniae (MP) infection group, bacteria infection group, MP and bacteria mixed infection group (mixed infection group) according to different pathogens. Thirty healthy children in the same period were selected as the control group. The serum vitamin A concentration was detected by ultra-high-performance liquid chromatography-tandem mass spectrometry. Results The level of serum vitamin A was (0.567±0.163) μmol/L in pneumonia group, (0.578±0.162) μmol/L in MP infection group, (0.557±0.153) μmol/L in bacteria infection group and (0.554±0.186) μmol/L in mixed infection group, and all of them were lower than that in control group (0.759±0.160) μmol/L, and there were significant differences (P<0.05). There was no difference in serum vitamin A level among MP infection group, bacteria infection group and mixed infection group (P>0.05). There was a significant difference in the distribution of vitamin A deficiency between pneumonia group and control group ( P<0.001). The proportion of suspected subclinical vitamin A deficiency in control group was higher, while vitamin A deficiency and subclinical vitamin A deficiency in pneumonia group were higher. Conclusions The serum vitamin A level decreased in children with community-acquired pneumonia, But there was no significant differences in serum vitamin A levels among the children with pneumonia caused by different pathogens.%目的 探讨社区获得性肺炎患儿血清维生素A水平的变化及意义.方法 选取2015年10月—2016年3月住院确诊的80例社区获得性肺炎患儿(肺炎组)为研究对象,并根据不同病原体感染分为肺炎支原体感染组、细菌感染组、支原体与细菌混合感染组(混合感染组);选取同期健康儿童30例为对照组.用超高效液相串联质谱法检测各组血清维生素A浓度并进行分析比较.结果 肺炎组血清维生素A水平为(0.567 ± 0.163)μmol/L,其中肺炎支原体感染组为(0.578 ± 0.162)μmol/L、细菌感染组(0.557 ± 0.153)μmol/L、混合感染组(0.554 ± 0.186)μmol/L,均低于对照组的(0.759 ± 0.160)μmol/L,差异有统计学意义(P<0.05);但肺炎支原体感染组、细菌感染组、混合感染组之间的差异无统计学意义(P>0.05).肺炎组与对照组维生素A缺乏分布的差异有统计学意义(P<0.001),肺炎组维生素A缺乏及亚临床维生素A缺乏检出率明显高于对照组,对照组可疑亚临床维生素A缺乏检出率高于肺炎组.结论 社区获得性肺炎患儿存在着血清维生素A水平下降;不同病原体感染肺炎患儿的血清维生素A水平无明显差异.