Objective To investigate the clinical characteristics of neonatal inflammatory bowel disease (IBD). Methods The clinical data of two neonates diagnosed with IBD. Clinical manifestation, laboratory examination, imaging, endoscopy and histopathological findings, treatment plan and prognosis were included. Results The clinical manifestations were fever, diarrhea, oral ulcer in two cases of neonatal IBD in this study. Laboratory findings showed inflammatory indicators (such as white blood cells, C-reactive protein) increased mainly accompanied by decreased hemoglobin, platelet, plasma albumin and other indicators. Endoscopic and pathological manifestations were significantly different in ulcerative colitis (UC) and Crohn disease (CD) children. The lesions range of UC patients were mainly sigmoid colon, and CD patients ileocecal. Conclusions For neonates with highly suspected IBD, positive endoscopy and gene detection are recommended. Early diagnosis and standard treatment are important. For children with refractory IBD with IL-10 and IL-10 receptor gene mutations, hematopoietic stem cell transplantation is feasible and could improve its prognosis.%目的 分析新生儿炎症性肠病(IBD)的临床特点.方法 回顾分析2例确诊IBD新生儿的临床资料,并复习相关文献.结果 2例新生儿IBD均为男性,均表现为腹泻、口腔溃疡、发热;均有白细胞计数、C反应蛋白、降钙素原升高,血红蛋白、血小板、血浆白蛋白下降;抗感染、输血、补充白蛋白等治疗无效;经内镜检查和基因检测确诊新生儿克罗恩病(CD).结论 对于高度怀疑新生儿期起病的IBD,应积极行消化内镜及基因检测,尽早确诊并予规范治疗.
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