急性药物性肝病诊治时机与预后关系的探讨

摘要

目的 对照比较药物致肝损害初期及时诊治与肝损害自然演变过程中实施诊治对病情和预后的影响。方法 回顾性分析61例急性药物性肝病的致损伤药物、临床类型及诊治时机对预后的影响。结果 组1(动态监控组)与组2(对照组)治愈率(χ2＝7.04，P＜0.01)，好转率(χ2＝4.18，P＜0.05)，住院时间(χ2＝5.53，P＜0.05)比较，差异均有显著性。提示组1较组2住院时间短、恢复快、预后好。结论 使用可致肝损害的药物期间，动态检测肝功能，注意发现药物性肝病的肝外表现，及早发现亚临床肝损害，及时停药及处理，有助于改善急性药物性肝病患者的预后。%Objective To observe the influences of early diagnosis andtreatment timely on development of liver injury induced by drugs and its prognosis.Methods Sixty-one patients with actue hepatitis induced by drug were divided into two groups,the early diagnosis,treatment group(group 1) and late diagnosis,treatment group(group 2),and compared the prognosis of two group.Results The cure rate(χ2＝7.04，P＜0.01)；effective rate (χ2＝4.18，P＜0.05)had obviously difference and the time of hospitalization was more short in the groups 1 patients,compared with groups 2 patients(χ2＝5.53，P＜0.05).Conclusions Early diagnosis and treatment of acute hepatitis is more helpful in prognosis in patients with acute hepatitis by drugs.Applicative period of drugs of induciable liver injury,the liver function should be dynamic determined,extrahepatic manifestation in drug-induced hepatitis should be attended,subclinical injury should be found out,as soon as possible and withdrawal the drugs timely,all these measures were helpful in improving prognosis of patients with drug-induced hepatitis.