首页> 中文期刊> 《中国医师杂志》 >周围型非小细胞肺癌CT征象与p21蛋白表达相关性研究

周围型非小细胞肺癌CT征象与p21蛋白表达相关性研究

摘要

Objective To study correlation between CT appeara nce and p21 expr ession in peripheral non-small cell lung cancer(NSCLC).Method Se venty-two cases of surgic ally and pathologically confirmed peripheral NSCLC were examined with computerized t omography before operation.The p21 expression was assessed by immunohistoche mica l technique in paraffin embedded tumor samples with the streptavidin peroxidas e conjugated method.Results:⑴p21 expression of tumors with diam eter over 3cm wa s significantly higher than those of 3cm or less;and p21 expression of tumors wi th deep lobulation or spiculate protuberance and mediastinal lymph node enlargem ent was higher than those without.⑵p21 expression was correlated with the degre e of tumor cell differention and histological typing.The CT appearance of peri pheral NSCLC with diameter over 3cm,deep lobulation or spiculate protuberance an d mediastinal lymph node enlargement were closely correlated with p21 expression ,which indicates higher degree of malignancy.Conclusions:There are correlations bet ween CT imaging and p21 expression of NSCLC,it might play a role in peripheral NSCLC prognosis.%目的:探讨周围型非小细胞肺癌(NSCLC)的CT征像与p21蛋白表达 的相关性。方法:对72例经手 术病理证实的周围型NSCLC术前进行CT扫描,并用SP法对肿瘤标本p21蛋白进行免疫组化染 色 。结果:⑴CT显示肿瘤的直径>3cm及有深分叶征、棘状突起、纵隔淋巴结 肿大者p21蛋白表达升高 。⑵肺癌的p21蛋白表达与肿瘤分化程度及组织学类型有关。结论:周围型N SCLC的CT征像中肿瘤的 直径>3cm,深分叶征、棘状突起及纵隔淋巴结转移与p21蛋白表达密切相关,具有相对更高 的恶性程度,可作为推测预后的指标。

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