Protective effects of bactericidal/permeability-increasing protein against hemorrhagic shock and its mechanism

摘要

Effects of bactericidal/permeability-increa protein(BPI, 1. 5 and 3. 5 rug/kg iv at the beginning of shock and resuscitation respectively) on the outcome of hemorrhagic shock was investigated in rats. Itwas found that BPI administration could improve hepatic and renal functions after hemorrhagic shock, andenhance the survival rate of the rats with shock (BPI group: 81 % vs physiological saline group: 44 %, P <0.05). In BPI group, the plasma endotoxin level was not significantly changed (0. 20± 0. 04 at the end of resuscitation vs 0. 24± 0. 05 U/ml before shock). Tumor necrosis factor. and interleukin-6 levels in BPI group, although higher after shock and resuscitation, were significantly lower than those in physiologia saline group.It is suggested that BPI exerts a protective effects on rats with hernorrhagic shock, which might be due to itsaction against hemorrhage-induced endotoxin translocation and its inhibition of cytokine responses in shock,