PDGF-BB/PDGFR-β与肿瘤发生发展的研究进展

摘要

血小板衍生生长因子(platelet-derived growth factor,PDGF)是一类重要的促血管生成因子,是多种细胞的促有丝分裂剂和趋化因子,血小板衍生生长因子受体(platelet-derived growth factor receptor,PDGFR)是络氨酸蛋白激酶家族成员,能促进细胞的趋化增殖,PDGF和PDGFR在肿瘤发生发展中起着重要作用,以PDGF/PDGFR为靶点作为肿瘤靶向治疗的研究也有了较大的进展.%Platelet-derived growth factor (PDGF) is a kind of angiogenic factor,is a variety of cell mitogenic agents and chemokines,platelet-derived growth factor receptor (PDGFR) is a member of the lysine protein kinase,which can promote the chemotaxis of cells.PDGF and PDGFR play an important role in the development of tumor.The study of PDGF/PDGFR as a target for tumor therapy has also made great progress.In this paper,review the progress of PDGF-BB/PDGFR-β in the development of tumor and the progress of tumor targeting therapy.