颅脑疾病患者血清超氧化物歧化酶检测结果分析

摘要

Objective To investigate the relationship of serum snperoxide dismutase (SOD) concentration and brain diseases . Methods Blood samples of patients with brain diseases (disease group) were collected and healthy subjects (contrast group) were collected for the white blood cell count (WBC),serum SOD and high sensitive C reactive protein (hs-CRP) concentration detection . Analyze the relationship of SOD concentration and diseases,analyze correlation of SOD to WBC and hs-CRP .Results The SOD concentration of disease group serum was (101 .7±60.1) U/mL,the control group was (137 .7±ll .9) U/mL,the SOD concentration of disease group was lower than contrast group with significant difference (P<0 .05) .For patients in disease group,serum SOD concentration and WBC count and hs-CRP concentration was negatively correlated,correlation coefficients were 0 .43 and 0 .30 (P<0 .05) .Conclusion The serum SOD levels of patients with brain diseases tend to be lower,anti-inflammatory treatment and application of free radical scavenger in the treatment of the recovery of the disease may have a positive significance.%目的 探讨颅脑疾病患者血清中超氧化物歧化酶(SOD)浓度与疾病的关系.方法 采集颅脑疾病患者(疾病组)及健康体检者(对照组)血样,作WBC计数及血清中SOD和超敏C反应蛋白(hs-CRP)浓度测定.分析SOD浓度与疾病的关系及SOD浓度与WBC计数、hs-CRP的相关性.结果 疾病组血清SOD浓度为(101.7±60.1)U/mL,对照组为(137.7±11.9)U/mL,疾病组SOD浓度较对照组低(P<0.05);疾病组血清SOD浓度与WBC计数及hs-CRP浓度呈负相关,相关系数分别为-0.43和-0.30(P<0.05).结论颅脑疾病患者血清SOD水平有明显的下降趋势,抗炎治疗及应用自由基清除剂治疗可能对疾病的恢复有积极的意义.