ICTP作为肿瘤骨转移诊断指标的价值分析

摘要

目的 统计并计算Ⅰ型胶原吡啶交联终肽(ICTP)作为诊断方法诊断肿瘤患者骨转移的灵敏度、特异度和准确性,分析ICTP作为肿瘤骨转移诊断指标的价值.方法 将2011年5月至2012年5月收治的肿瘤患者46例按照明确病理诊断和影像学诊断,分为肿瘤骨转移组即观察组和肿瘤未骨转移组即对照组,检测患者血清中ICTP的含量,ICTP值参考范围:1.5～4.3 μL,诊断患者是否已经发生了骨转移,统计取真率即灵敏度、弃伪率即特异度、正确诊断出肿瘤骨转移的概率与正确诊断出未发生肿瘤骨转移的概率之和即准确性,再通过独立样本资料的2×2列联表2检验,计算ICTP单独诊断肿瘤骨转移是否具有显著差异.结果 ICTP作为诊断指标诊断肿瘤患者骨转移的灵敏度为69.0％,特异度为29.4％,准确性为54.3％.通过独立样本资料的2×2列联表x2检验,ICTP单独诊断肿瘤骨转移不具有显著差异.结论 ICTP作为肿瘤骨转移诊断指标具有良好的灵敏度,但是单独作为诊断指标诊断肿瘤是否骨转移不具有显著性的差异,即单独诊断不具有良好的诊断效果,配合其他骨代谢的生化指标诊断肿瘤骨转移具有理想的效果,值得发展和推广.%Objective To statistics and calculation of collagen type Ⅰ pyridine end of the cross-linked peptide(ICTP) as a diagnostic method,the sensitivity,specificity,and accuracy of the diagnosis of cancer patients with bone metastases,analysis of the value of ICTP as a diagnostic indicator of bone metastases.Methods From May 2011 to May 2012,46 cases of cancer patients admitted to the hospital,the observation group and the tumor was not bone metastasis into bone metastases group as the control group,the detection of patients in accordance with a clear pathological diagnosis and imaging diagnosis serum ICTP content the ICTP value reference range:1.5-4.3μL diagnosis patients had happened bone metastases,statistical sensitivity,specificity abandoned pseudo rate,correctly diagnosed the probability of correct diagnosis of bone metastases the probability of bone metastases did not occur and that the accuracy of c 2 test,2 × 2 contingency table data through independent samples calculated ICTP separate diagnosis of bone metastases whether significant differences.Results ICTP as a diagnostic indicator diagnostic sensitivity of cancer patients with bone metastases was 69.0％,specificity 29.4 ％,accuracy 54.3 ％.c 2 test by the independent sample data 2 × 2 contingency table,ICTP diagnosis of bone metastases alone had no significant difference.Conclusion ICTP,as a tumor bone metastasis diagnosis indicators has good sensitivity,but individually as whether diagnostic indicators diagnosis of tumor bone metastasis not have a significant the differences that separate diagnosis does not have a good diagnostic effect with other bone metabolism of biochemical markers diagnostic tumor bone metastases have the desired effect,and worthy of development and promotion.