乌头半夏反药组合宜忌条件的实验研究回顾与评析

摘要

This article summarized the suitable conditions and contraindicant conditions of antagonism compatibility aconitum and pinellia ternate from the selected experimental research articles by searching “aconite and Pinellia ternate compatibility of Chinese medicine eighteen antagonism” from Wan Fang, CNKI, and VIP database since 1949. We preliminarily concluded that when the compatibility ratio of aconitum and pinellia ternate is 1:2, the damage for heart, liver and kidney is highest. On the method of preparation, the decoction of two herbs is more toxic than the combined solutions of single herb decoction. Different processing of the two herbs give different experiment results even though on the certain ratio, so it’ s hard to conclude the optimum condition. More researches should be done to get the essence of the two-contraindicated herbs so that improving the compatibility theory of traditional Chinese medicine and clinical value.%利用中国知网、万方、维普、PUBMED数据库，系统检索自1949年至今，有关“十八反”中乌头与半夏反药组合同用的文献，检索文章的过程中剔除综述及临床研究类文章，选取实验研究方面的文章，总结归纳乌头半夏反药组合配伍使用的宜忌条件。初步认为生川乌与生半夏1：2配伍为实验的禁忌条件，对心、肝、肾组织的损害大，各高、中、低剂量组(相当于临床成人剂量的45倍、10~15倍、3~6倍)之间无差异，就其煎煮方式而言，合煎液比合并液的毒性强；由于乌头与半夏有不同的炮制品种，即使在相同的比例下进行实验也会出现不同的结果，比例方面尚不能归纳其适宜条件。而给药时间、煎煮方式方面的研究较少，很难从少量的实验中总结归纳出宜忌条件。笔者认为乌头半夏能否同用不能一概而论，而是受到不同条件的限制。即对乌头半夏这一反药组合配伍应进行多角度、多学科、多层次的探析以期最终阐明乌头与半夏的配伍实质，为完善中药配伍理论和指导临床运用起到重要的理论意义和临床价值。