Objective To compare preventive and therapeutic effects of milrinone, phenoxybenzamine and nitroglycerin on human radial artery spasm. Methods The radial artery samples of 20 patients who underwent coronary artery bypass graft surgery (CABG) were collected, and were cut into 3 mm wide of circulus vasculosuses. The therapeutical effects for excised spasm radial artery of Milrinone (MIN group) , phenoxybenzamine (PHE group) and nitroglycerin (NTG group) were compared by Organ Bath technique, and irritative reactions of radial arteries with medicamentous pretreatment to cause spasm factors were observed. Results In relaxed spasm experiment, the completely relaxed time of radial arteries in NTG group was the fastest, and the differences between NTG group with MIN and PHE groups were of statistical significance (P 0. 05); the differences of the 3 drug groups and control group were of statistical significance (P < 0. 05). Conclusion Milrinone, phenoxybenzamine and nitroglycerin can prevent and relieve vasospasm of radial arteries in different levels, and the NTG can effectively release the spasmed radial arteries, while the PHE can do a wonderful job in pretreatment procedure.%目的 比较米力农、酚苄明和硝酸甘油对人桡动脉痉挛的防治作用.方法 收集20例冠状动脉旁路移植手术(CABG)者的桡动脉标本,制成3 mm宽的血管环.利用Organ-Bath技术比较米力农(米力农组)、酚苄明(酚苄明组)、硝酸甘油(硝酸甘油组)对离体痉挛桡动脉的治疗作用,并观察经药物预处理后桡动脉对致痉挛因素刺激的反应情况.结果 痉挛缓解实验中,硝酸甘油在痉挛桡动脉完全舒张时间上最迅速有效,与米力农和酚苄明比较差异有统计学意义(P＜0.01)；酚苄明与米力农比较差异亦有统计学意义(P＜0.01)；3组药物组均较空白对照组有效(P＜0.01).痉挛预防实验中,酚苄明组产生静息张力的平均药物剂量明显低于硝酸甘油组与米力农组(P＜0.05)；硝酸甘油组与米力农组比较无统计学意义(P＞0.05)；3组药物组与空白对照组比较均有统计学意义(P＜0.05).结论 米力农、酚苄明、硝酸甘油都能不同程度地预防和缓解桡动脉痉挛,硝酸甘油对缓解已痉挛的桡动脉最有效,而经酚苄明预处理的桡动脉最不易产生新的痉挛.
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