Shining more light on G protein signalling modules:a novel optogenetic tool for Gq activation

摘要

The use of optogenetic and chemogenetic approaches to control cellular activities with high temporal,spatial and cell-type specific resolution has profoundly transformed the field of neuroscience.In addition to enabling the manipulation of neuronal excitability,there is a great need for targeting intracellular signalling proteins and secondary messengers precisely。