福州市人群甲型H1N1流感血清流行病学研究

摘要

目的 了解在不同流行时期福州市人群的甲型H1N1流感(甲流)血清抗体水平.方法 自2009年11月30日至2010年3月22日,共5次在福州市的4家医院和1家采供血机构随机选择调查对象,每次调查采集400例血清.以血凝抑制试验方法(haemagglutination inhibition,HI)检测血清HI抗体.结果 5次调查的人群甲流HI抗体阳性率依次为1.75％、8.00％、11.25％、12.50％和14.25％,抗体几何平均滴度(GMT)则分别为5.49、6.81、7.59、8.83和8.54.不同时间段之间抗体阳性率和GMT的差异有显著统计学意义(P＜0.01).4个年龄组中,以6-17岁的抗体阳性率和GMT的增长幅度最大且有显著统计学意义(P＜0.01).男女性别之间抗体水平差异无统计学意义(P＞0.05).在接种甲流疫苗的人群中,抗体阳性率和GMT分别为46.43％和28.99,均显著高于非接种者的7.20％和6.76(P＜0.01).结论 至2010年3月20日,福州市人群甲流抗体水平显著提高,已初步形成免疫屏障,但应加强重点人群的防控措施.%This study was aimed at investigating the serologic responses to 2009 pandemic influenza A (HIND virus in Fuzhou City, China. Serum specimens were collected from subjects at five different periods from November 30, 2009 to March 22. 2010,and tested by use of haemagglutination inhibition (HI) assay. The results showed that the positive rates of HI antibody were 1.75%, 8.00%, 11.25%, 12.50% and 14.25% (P<0.01), and HI Geometric Mean Titer (GMT) were 5.49. 6. 81, 7.59. 8. 83 and 8. 54 (P<0. 01) at five different periods respectively. Among 4 different age groups, 6-17 age group showed the largest increments on the positive rates of HI antibody and GMT (P<0. 01). There was no significant difference in the levels of HI antibody between males and females (P>0. 05). The positive rates of antibody and GMT in the subjects received H1N1 vaccination were 46.43% and 28. 99, which were significantly higher than those in the subjects without vaccination (7. 20% and 6. 76) (P<0. 01). The data revealed that the levels of HI antibody had been significantly increased and, to some extent, the development of immunological barrier to 2009 pandemic influenza A (HIND virus had been formed in Fuzhou City. However, the preventive measures targeting the key age groups should be strengthened.