Synthesis and Crystal Structure of （5-Hydroxy-6-methoxybenzofuran- 3-yl）-（4-methoxyphenyl）methanone

摘要

Compound 1 (5-hydroxy-6-methoxybenzofuran-3-yl)(4-methoxyphenyl)metha- none, C17H1405, as a potential anti-breast cancer agent has been synthesized under microwave irradiation, which was further converted to (5,6-dihydroxybenzofuran-3-yl)(4-methoxyphenyi)me- thanone (2). The compounds were characterized by MS and NMR spectra. Meanwhile, the crystal of 1 was obtained and determined by X-ray single-crystal diffraction. Crystal data: monoclinic system, space group P2, a = 8.908(6), b = 10.505(7), c = 15.452(11) A, β = 105.043(9), V = 1396.4(16) A3, Z = 4, F(000) = 624, Dc = 1.419 g/cm3, p = 0.105 mm-1, R = 0.0513 and wR = 0.1246 for 14459 independent reflections (Rint = 0.0647) and 2488 observed ones (I〉 2σ(/)). lntermolecular O-H...O and π-π stacking interactions contributed to the stability of the structure.