足细胞,作为肾小球滤过屏障的一道重要防线,被认为是蛋白尿产生的中心环节,因此近年来备受关注.免疫抑制剂对足细胞损伤的保护作用促使人们寻找除其免疫抑制作用之外对足细胞直接的保护机制.足细胞本身是否具有免疫细胞样的特性?在病理情况下,足细胞又是如何对机体炎症反应作出应答的?上述问题的解答将对足细胞损伤机制研究和探寻治疗干预措施具有重要意义.%The podocyte, an important barrier of glomendar filter, is considered to be the central point, of developing proteinuria. The effect of immunosuppressants on proteinuria reduction and podocyte injury reverse urged people to find its direct role on podocyte besides its immunosuppression. Does the podocyte have immune cells-like characters? Or how does the podocyte respond to inflammatory reaction in pathological condition? The solution to these questions will be helpful to investigate the mechanism and find therapeutic methods of podocyte injury.
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