Objective To analyze the correlations between energy spectral computed tomography (CT) quantitative parameters and biomechanics, and explore the value of energy spectral CT quantitative parameters in the assessment of bone strength. Methods Energy spectral CT scanning was performed on 36 vertebral bodies to determine the density of CT-based material pairs (iron-water, calcium-water and hydroxyl-phosphorus) in cancellous, cortex and cortico-cancellous in each vertebral body of the sheep. Then the corresponding number of each vertebral body was removed, and lumbar compression experiment was conducted. The correlations between the density values of different pairs (iron-water, calcium-water and hydroxyapatite-water) and the maximum load and maximum stress measured by biomechanics were analyzed. Results The analysis of the correlations between density values and biomechanical properties of energy spectral CT-based materials showed that for cortico-cancellous, calcium-water and hydroxyapatite-water were strongly correlated with the maximum stress (R2=0.508, P<0.05; R2=0.507, P<0.05), and moderately correlated with the maximum load (R2=0.454, P<0.05;R2=0.451, P<0.05), while the iron-water correlation was relatively lower. The 3 CT-based material pairs of cortex and cancellous had poor correlations between density values and biomechanical properties. Conclusion Energy spectral CT quantitative parameters can be used to evaluate bone strength.%目的:通过分析能谱CT定量参数与生物力学的相关性,探讨能谱CT定量参数评估骨强度的价值.方法:采用能谱CT成像扫描36个羊腰椎椎体,测定每个椎体的骨松质、骨皮质及皮质+松质的能谱CT基物质对(铁-水、钙-水、羟基磷灰石-水)密度,然后将各个椎体去除附件对应编号,行腰椎压缩实验.将能谱不同基物质对(铁-水、钙-水、羟基磷灰石-水)密度值与生物力学测得的最大载荷和最大应力进行相关性分析.结果:能谱CT基物质对密度值与生物力学相关性分析可得,在松质+皮质时钙-水、羟基磷灰石-水与最大应力呈强相关(R2=0.508, P<0.05; R2=0.507, P<0.05),与最大载荷呈中等程度相关(R2=0.454, P<0.05; R2=0.451, P<0.05),而铁-水相关性较低;皮质、松质的3个基物质对密度值与生物力学值相关性较差.结论:能谱CT定量参数可以用来评价骨强度.
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