Objective To analyze the reasonable dosage of urokinase in patients with lower limb deep vein thrombosis (DVT) treated with catheter-directed thrombolysis (CDT). Methods Ninety patients with DVT who would be treated with CDT were randomly divided into three groups. Patients in group A were given with low dose of urokinase (＜ 400 000 U per day, in group B with medium dose (400 000 U-800 000 U per day) , while group C with larger dose urokinase (＞800 000 U per day). The thrombolysis effect, thrombolytic treatment time and hemorrhage situation were compared among the three groups. Results The thrombolytic therapy effect were different among three groups ( Hc = 15. 09 , P ＜0. 05). The effect were different between group A and group B (t=l. 99, P<0. 05). Thrombolytic time difference had statistical significance (F=4. 92, P＜0. 05). No statistical significance of hemorrhage was found among three groups (x2 = 2. 96, P＞0. 05). Hemorrhage of group C was the most serious. Conclusion CDT for treatment of DVT is safe and effective. Using urokinase 400 000-800 000 U per day, the thrombolytic effect is good, and the rate of hemorrhage remains low.%目的 探讨经导管直接溶栓(CDT)治疗下肢深静脉血栓中尿激酶的合理用量.方法 将拟接受CDT的90例DVT患者随机分为3组:A组用小剂量尿激酶溶栓(每日用量＜40万U),B组用中等剂量(每日用量40万～80万U),C组用大剂量(每日用量＞80万U)进行溶栓治疗.比较3组的溶栓效果、溶栓时间及出血情况.结果 3组溶栓疗效差异有统计学意义(Hc=15.09,P＜0.05),A组与B组疗效差异有统计学意义(t=1.99,P＜0.05).3组溶栓时间差异有统计学意义(F=4.92,P＜0.05).各组出血发生率差异无统计学意义(x2=2.96,P＞0.05),C组出血程度最重.结论 CDT治疗DVT安全有效,每日尿激酶用量在40万U～80万U时溶栓疗效好,且出血发生率低.
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