非高密度脂蛋白与颈动脉粥样硬化程度的相关性研究

摘要

Objective To study the association between serum non-HDL-C level and carotid atherosclerosis (CAS).Methods The clinical data of 1209 patients with their age＞60 years admitted to our hospital for physical examination were retrospectively analyzed.The patients were divided into mild CAS group (n=613) and moderate-severe CAS group (n=596).Their clinical data (sex,age,hypertension,DM and cigaret smoking) were recorded,their serum HDL-C and LDL-C levels were measured and analyzed.Results The age was significantly older,the number of famels and cigaret smokers was significantly greater,the incidence of hypertension and DM and the serum non-HDL-C level were significantly higher in moderate-severe CAS group than in mild CAS group (P＜0.05).Multivariate logistic regression analysis showed that serum non-HDL-C level and DM were the independent risk factors for CAS.Conclusion The serum non-HDL-C level is positively associated with CAS and is thus an independent risk factor for CAS.%目的 探讨非HDL-C水平与颈动脉粥样硬化(CAS)改变程度之间的关系.方法 回顾性分析就诊于北京市海淀医院体检中心的年龄＞60岁既往无脑卒中或心肌梗死病史的1209例体检者临床资料,根据颈动脉超声结果将其分为2组,无或轻度CAS组613例与中重度CAS组596例.采用调查问卷获取体检者的临床基线资料,包括性别、年龄、高血压、糖尿病、吸烟等.采用终点测试法测定TC,直接测试法测定HDL-C和LDL-C水平,进行统计分析.结果 与无或轻度CAS组比较,中重度CAS组年龄、女性、吸烟、高血压、糖尿病比例及非HDL-C水平均显著升高,差异有统计学差异(P＜0.05).多因素logistic分析显示,非HDL-C水平(OR=1.876,95％CI:1.322～3.541)和糖尿病(OR=2.123,95％CI:1.671～4.723)是CAS改变程度的独立危险因素.结论 非HDL-C与CAS程度呈正相关,且是反应CAS严重程度的独立危险因素.