目的 探讨高同型半胱氨酸(Hcy)血症与动脉粥样硬化的相关性.方法 测定脑梗死组和健康对照组的血清Hcy,利用彩色多普勒超声检查各组颈动脉粥样硬化情况,对比老年脑梗死患者和正常人的血清Hcy水平.结果 脑梗死组血清Hcy水平为(19.63±6.74)μmol/L,而健康对照组血清Hcy水平为(13.76±3.95)μmol/L,两组比较差异有统计学意义(P<0.05).血清Hcy水平与IMT增厚有显著相关性(P=0.004).结论 高Hcy血症是动脉粥样硬化形成的重要原因,是脑梗死发病的独立危险因素.%Objective To investigate the association between the Hcy and atheroma progression in aged patients with cerebral infarction. Methods 60 consecutive hospitalized cerebral infarction patients whose carotid intimamedia thickness(IMT) more than 1.2mm and 42 healthy controls were chosen in our study. Serum Hcy level was determined, and carotid atheroma was detected by color doppler ultrasound. Results The serum Hcy of the patient was higher significantly than that of the normal controls. The serum Hcy level was significantly associated with atheroma( P =0.004). Conclusion The high serum Hcy level is an independent risk factor for cerebral infarction.
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