Objective To observe the effect of alorvaslalin on oxidalive slress and Lipid peroxidalion in senile palienls with ischemic slroke. Methods 62 palienls were divided in conlrol group < n =30) and experimental group (n =32) . Palienls in conlrol group were given rouline treatment, while palienls in experimental group were given alorvaslalin besides rouline treatment. Plasma levels of ox-LDL and SOD were measured by ELISA method, ox-LDL and SOD were measured in two groups before and after treatment. Results After 10 ~ 14 days therapy, serum ox-LDL and SOD in experimental group were not change more. But ox-LDL levels in the conlrol group was higher than thai of admission ( P < 0. 01) and SOD level was lower than that of admission ( P < 0. 01 ) . Conclusion Alorvaslalin may play an important role in the treatment and impromenl of prognosis of acute cerebral infarction from anlioxidanl.%目的 分析阿托伐他汀在治疗老年急性缺血性脑卒中的抗氧化应激作用.方法 将62例急性脑梗死患者随机分为对照组(30例)和研究组(32例),对照组给予常规药物治疗;研究组在常规药物治疗的基础上加用阿托伐他汀治疗.用ELISA法检测患者氧化低密度脂蛋白(ox-LDL)水平和超氧化物歧化酶(SOD)浓度,比较两组患者治疗前后ox-LDL和SOD水平的变化情况.结果 治疗10～14 d后研究组ox-LDL和SOD水平较入院时无明显变化,而对照组ox-LDL的水平较入院时升高[(48.46±9.47)×10-5mmol/L比(55.54±8.55)×10-5mmol/L,P<0.01],SOD水平较入院时降低[(20.52±6.66)u/ml比(17.99±5.89)u/ml,P<0.01].两组治疗后ox-LDL、T-SOD比较,均P<0.05.结论 阿托伐他汀从抗氧化应激的角度,可能对急性脑梗死的治疗及预后起重要作用.
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