不同糖耐量人群血清维生素D水平的变化

摘要

Objective To explore the level of serum Vitamin D with different degrees of impaired glucose toler-ance.Methods according to the level of blood glucose,Seventy-nine patients were divided into normal glucose toler-ance group(NC group),impaired glucose tolerance group(IGT group)and T2DMgroup according to the level of blood glucose 25-Hydroxyvitamins D(25(OH)D3)and related metabolic parameters were compared.Results The 25(OH) D3 has the digression trend in the NC group,IGT group and T2DMgroup.There were significant difference on p2hBG, TG,LDL,BMI,HOMA-IR and 25(OH)D3 among three groups.Multiple regression analysis indicates 25(OH)D3 was positively correlated with HOMA-IR and BMI was negatively correlated with HOMA-IR.Conclusion Vitamin D is re-lated to glucose metabolism,and may contribute to insulin resistance.%目的：探讨血清维生素 D 在不同糖耐量状态下的变化。方法根据血糖水平将79例受试者分为糖耐量正常组（NC 组）、糖耐量减低组（IGT 组）和2型糖尿病组（T2DM组），比较不同组间25羟维生素 D3[25（OH）D3]水平及相关代谢指标的差异。结果25（OH）D3在 NC 组、IGT 组和 T2DM组呈递减趋势，NC 组、IGT 组和 T2DM组这三组间在餐后2h 血糖、三酰甘油、低密度脂蛋白、体质量指数、稳态胰岛素评价指数（HOMA-IR）和25（OH）D3上差异有统计学意义。进一步行多元回归分析显示，25（OH）D3与 HOMA-IR 正相关，BMI 与 HOMA-IR 负相关。结论维生素 D 与糖代谢相关，可能参与了胰岛素抵抗。